Frank van Leth - The effect of tuberculosis and antiretroviral

Journal article

M. Brouwer, Paula Samu Gudo, Chalice Mage Simbe, P. Perdigão, F. van Leth
BMC Public Health, 2012

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Brouwer, M., Gudo, P. S., Simbe, C. M., Perdigão, P., & van Leth, F. (2012). The effect of tuberculosis and antiretroviral treatment on CD4+ cell count response in HIV-positive tuberculosis patients in Mozambique. BMC Public Health.

Chicago/Turabian Click to copy
Brouwer, M., Paula Samu Gudo, Chalice Mage Simbe, P. Perdigão, and F. van Leth. “The Effect of Tuberculosis and Antiretroviral Treatment on CD4+ Cell Count Response in HIV-Positive Tuberculosis Patients in Mozambique.” BMC Public Health (2012).

MLA Click to copy
Brouwer, M., et al. “The Effect of Tuberculosis and Antiretroviral Treatment on CD4+ Cell Count Response in HIV-Positive Tuberculosis Patients in Mozambique.” BMC Public Health, 2012.

BibTeX Click to copy

@article{m2012a,
  title = {The effect of tuberculosis and antiretroviral treatment on CD4+ cell count response in HIV-positive tuberculosis patients in Mozambique},
  year = {2012},
  journal = {BMC Public Health},
  author = {Brouwer, M. and Gudo, Paula Samu and Simbe, Chalice Mage and Perdigão, P. and van Leth, F.}
}

Abstract

BackgroundTuberculosis (TB) presents a serious problem in Mozambique. HIV prevalence among TB patients is estimated at 47%. A delay in having their first CD4+ cell count could lead to a missed opportunity for ART initiation due to a CD4+ cell increase above the cut-off caused by TB treatment. The objective is to describe CD4+ cell response during TB treatment and quantify the effect of TB treatment and ART on this response.MethodsAll new HIV + adult TB cases in 2007 from three TB clinics in Mozambique were included. Data on TB diagnosis and treatment and HIV parameters were collected. A general mixed model was used for CD4+ cell count response.Results338 HIV + patients were notified and 252 (75%) were included in the analysis. Using TB medication was not independently associated with the CD4+ count response (19 cells/mm3; 95% CI: -40 to 79; p = 0.529). ART-use was associated with statistically significantly higher CD4+ cells compared to no ART-use (81 cells/mm3; 95% confidence interval (CI): 12 to 151; p = 0.022).ConclusionIn this study, no independent effect of TB treatment on CD4+ cell count was found. HIV-infected TB patients on ART had a significantly higher CD4+ cell count than those not receiving ART. CD4+ cell counts for patients not on ART at TB treatment start, remained below the cut off for initiating ART during the first three months of TB treatment; therefore some delay in getting the first CD4+ cell count would not lead to missing the opportunity to start ART.