Frank van Leth - Management of patients with

Journal article

C. Lange, I. Abubakar, J. Alffenaar, G. Bothamley, J. Caminero, A. C. Carvalho, K. Chang, L. Codecasa, A. Correia, V. Crudu, P. Davies, M. Dedicoat, F. Drobniewski, R. Duarte, C. Ehlers, C. Erkens, D. Goletti, G. Günther, E. Ibraim, B. Kampmann, L. Kukša, W. D. de Lange, F. van Leth, J. van Lunzen, A. Matteelli, D. Menzies, I. Monedero, E. Richter, S. Rüsch-Gerdes, A. Sandgren, A. Scardigli, A. Skrahina, E. Tortoli, G. Volchenkov, D. Wagner, M. J. van der Werf, B. Williams, W. Yew, J. Zellweger, D. Cirillo
European Respiratory Journal, 2014

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Lange, C., Abubakar, I., Alffenaar, J., Bothamley, G., Caminero, J., Carvalho, A. C., … Cirillo, D. (2014). Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement. European Respiratory Journal.

Chicago/Turabian Click to copy
Lange, C., I. Abubakar, J. Alffenaar, G. Bothamley, J. Caminero, A. C. Carvalho, K. Chang, et al. “Management of Patients with Multidrug-Resistant/Extensively Drug-Resistant Tuberculosis in Europe: a TBNET Consensus Statement.” European Respiratory Journal (2014).

MLA Click to copy
Lange, C., et al. “Management of Patients with Multidrug-Resistant/Extensively Drug-Resistant Tuberculosis in Europe: a TBNET Consensus Statement.” European Respiratory Journal, 2014.

BibTeX Click to copy

@article{c2014a,
  title = {Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement},
  year = {2014},
  journal = {European Respiratory Journal},
  author = {Lange, C. and Abubakar, I. and Alffenaar, J. and Bothamley, G. and Caminero, J. and Carvalho, A. C. and Chang, K. and Codecasa, L. and Correia, A. and Crudu, V. and Davies, P. and Dedicoat, M. and Drobniewski, F. and Duarte, R. and Ehlers, C. and Erkens, C. and Goletti, D. and Günther, G. and Ibraim, E. and Kampmann, B. and Kukša, L. and de Lange, W. D. and van Leth, F. and van Lunzen, J. and Matteelli, A. and Menzies, D. and Monedero, I. and Richter, E. and Rüsch-Gerdes, S. and Sandgren, A. and Scardigli, A. and Skrahina, A. and Tortoli, E. and Volchenkov, G. and Wagner, D. and van der Werf, M. J. and Williams, B. and Yew, W. and Zellweger, J. and Cirillo, D.}
}

Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking. TBNET consensus statement on the management of patients with MDR/XDR-TB has been released in the Eur Respir J http://ow.ly/uizRD