Frank van Leth

Associate Professor Health Sciences

Rifapentine access in Europe: growing concerns over key tuberculosis treatment component


Journal article


L. Guglielmetti, G. Günther, C. Leu, D. Cirillo, R. Duarte, A. García-Basteiro, D. Goletti, M. Jankovic, L. Kukša, F. Maurer, F. Mechaï, Simon Tiberi, F. van Leth, N. Veziris, C. Lange
European Respiratory Journal, 2022

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Guglielmetti, L., Günther, G., Leu, C., Cirillo, D., Duarte, R., García-Basteiro, A., … Lange, C. (2022). Rifapentine access in Europe: growing concerns over key tuberculosis treatment component. European Respiratory Journal.


Chicago/Turabian   Click to copy
Guglielmetti, L., G. Günther, C. Leu, D. Cirillo, R. Duarte, A. García-Basteiro, D. Goletti, et al. “Rifapentine Access in Europe: Growing Concerns over Key Tuberculosis Treatment Component.” European Respiratory Journal (2022).


MLA   Click to copy
Guglielmetti, L., et al. “Rifapentine Access in Europe: Growing Concerns over Key Tuberculosis Treatment Component.” European Respiratory Journal, 2022.


BibTeX   Click to copy

@article{l2022a,
  title = {Rifapentine access in Europe: growing concerns over key tuberculosis treatment component},
  year = {2022},
  journal = {European Respiratory Journal},
  author = {Guglielmetti, L. and Günther, G. and Leu, C. and Cirillo, D. and Duarte, R. and García-Basteiro, A. and Goletti, D. and Jankovic, M. and Kukša, L. and Maurer, F. and Mechaï, F. and Tiberi, Simon and van Leth, F. and Veziris, N. and Lange, C.}
}

Abstract

Rifapentine, a synthetic derivate of rifampicin which was developed in 1965, has interesting pharmacological properties, including a long terminal half-life (13 h, compared to 2–3 h for rifampicin) and promising bactericidal activity against Mycobacterium tuberculosis. Despite being approved in 1998 by the US Food and Drug Administration (FDA) for the treatment of pulmonary tuberculosis, its global use has been limited by unavailability. In the past decade, new evidence has emerged to define rifapentine as a key component for treatment of active disease and latent infection with M. tuberculosis (LTBI). Lack of access to rifapentine in Europe denies patients optimal care for active tuberculosis and latent tuberculosis infection, and deprives healthcare providers of adequate tools to pursue tuberculosis control and elimination https://bit.ly/3jz85eh